Reduced Local Growth and Spread but Preserved Pathogenicity of a ΔpurC Mycobacterium tuberculosis Auxotrophic Mutant in Gamma Interferon Receptor-Deficient Mice after Aerosol Infection

We compared the growth levels and pathogenicities of the Mycobacterium tuberculosis MT103 clinical strain with those of the ΔpurC mutant strain MYC1551, which is auxotrophic for purine in wild-type and gamma interferon receptor (IFN-γR)-deficient mice. The ΔpurC strain MYC1551 grew initially in both...

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Detalhes bibliográficos
Principais autores: Brown, Najmeeyah, Jacobs, Muazzam, Parida, Shreemanta K., Botha, Tania, Santos, Aldina, Fick, Lizette, Gicquel, Brigitte, Jackson, Mary, Quesniaux, Valerie, Ryffel, Bernhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC538938/
https://ncbi.nlm.nih.gov/pubmed/15618214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.1.666-670.2005
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