Surface-Active Fungicidal d-Peptide Inhibitors of the Plasma Membrane Proton Pump That Block Azole Resistance

A 1.8-million-member d-octapeptide combinatorial library was constructed in which each member comprised a diversity-containing N-terminal pentapeptide and a C-terminal amidated triarginine motif. The C-terminal motif concentrated the library members at the fungal cell surface. A primary screen for i...

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Detalhes bibliográficos
Main Authors: Monk, Brian C., Niimi, Kyoko, Lin, Susan, Knight, Allison, Kardos, Thomas B., Cannon, Richard D., Parshot, Rekha, King, Amanda, Lun, David, Harding, David R. K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC538910/
https://ncbi.nlm.nih.gov/pubmed/15616276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.1.57-70.2005
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