Association of CTLA-4 Gene Variants with Response to Therapy and Long-term Survival in Metastatic Melanoma Patients Treated with Ipilimumab: An Italian Melanoma Intergroup Study

Ipilimumab (IPI) blocks CTLA-4 immune checkpoint resulting in T cell activation and enhanced antitumor immunity. IPI improves overall survival (OS) in 22% of patients with metastatic melanoma (MM). We investigated the association of CTLA-4 single nucleotide variants (SNVs) with best overall response...

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書誌詳細
出版年:Front Immunol
主要な著者: Queirolo, Paola, Dozin, Beatrice, Morabito, Anna, Banelli, Barbara, Piccioli, Patrizia, Fava, Cristiana, Leo, Claudio, Carosio, Roberta, Laurent, Stefania, Fontana, Vincenzo, Ferrucci, Pier Francesco, Martinoli, Chiara, Cocorocchio, Emilia, Battaglia, Angelo, Ascierto, Paolo A., Capone, Mariaelena, Simeone, Ester, De Galitiis, Federica, Pagani, Elena, Antonini Cappellini, Gian Carlo, Marchetti, Paolo, Guida, Michele, Tommasi, Stefania, Mandalà, Mario, Merelli, Barbara, Quaglino, Pietro, Fava, Paolo, Guidoboni, Massimo, Romani, Massimo, Spagnolo, Francesco, Pistillo, Maria Pia
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2017
主題:
Immunology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388686/
https://ncbi.nlm.nih.gov/pubmed/28446908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00386
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