Association of CTLA-4 Gene Variants with Response to Therapy and Long-term Survival in Metastatic Melanoma Patients Treated with Ipilimumab: An Italian Melanoma Intergroup Study

Ipilimumab (IPI) blocks CTLA-4 immune checkpoint resulting in T cell activation and enhanced antitumor immunity. IPI improves overall survival (OS) in 22% of patients with metastatic melanoma (MM). We investigated the association of CTLA-4 single nucleotide variants (SNVs) with best overall response...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Queirolo, Paola, Dozin, Beatrice, Morabito, Anna, Banelli, Barbara, Piccioli, Patrizia, Fava, Cristiana, Leo, Claudio, Carosio, Roberta, Laurent, Stefania, Fontana, Vincenzo, Ferrucci, Pier Francesco, Martinoli, Chiara, Cocorocchio, Emilia, Battaglia, Angelo, Ascierto, Paolo A., Capone, Mariaelena, Simeone, Ester, De Galitiis, Federica, Pagani, Elena, Antonini Cappellini, Gian Carlo, Marchetti, Paolo, Guida, Michele, Tommasi, Stefania, Mandalà, Mario, Merelli, Barbara, Quaglino, Pietro, Fava, Paolo, Guidoboni, Massimo, Romani, Massimo, Spagnolo, Francesco, Pistillo, Maria Pia
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388686/
https://ncbi.nlm.nih.gov/pubmed/28446908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00386
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