In Vivo Resistance of a Laboratory-Selected Aspergillus fumigatus Isolate to Amphotericin B

The fungal burdens (number of CFU per pair of lungs) in mice infected with Aspergillus fumigatus AB16.4 (for which the amphotericin B [AMB] MIC was elevated) and W73355 (drug-susceptible parent) were reduced by 21 and 81%, respectively, after 5 days of AMB treatment (2 mg/kg/day), indicating that AB...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Manavathu, Elias K., Cutright, Jessica L., Chandrasekar, Pranatharthi H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2005
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC538856/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15616327/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.49.1.428-430.2005
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