Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA

Hepatitis B virus (HBV) replicates its DNA genome through reverse transcription of a viral RNA pregenome. We report herein that the interferon (IFN) stimulated exoribonuclease gene of 20 KD (ISG20) inhibits HBV replication through degradation of HBV RNA. ISG20 expression was observed at basal level...

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Pubblicato in:PLoS Pathog
Autori principali: Liu, Yuanjie, Nie, Hui, Mao, Richeng, Mitra, Bidisha, Cai, Dawei, Yan, Ran, Guo, Ju-Tao, Block, Timothy M., Mechti, Nadir, Guo, Haitao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388505/
https://ncbi.nlm.nih.gov/pubmed/28399146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006296
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