Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA

Hepatitis B virus (HBV) replicates its DNA genome through reverse transcription of a viral RNA pregenome. We report herein that the interferon (IFN) stimulated exoribonuclease gene of 20 KD (ISG20) inhibits HBV replication through degradation of HBV RNA. ISG20 expression was observed at basal level...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Liu, Yuanjie, Nie, Hui, Mao, Richeng, Mitra, Bidisha, Cai, Dawei, Yan, Ran, Guo, Ju-Tao, Block, Timothy M., Mechti, Nadir, Guo, Haitao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388505/
https://ncbi.nlm.nih.gov/pubmed/28399146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006296
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