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Misincorporation by RNA polymerase is a major source of transcription pausing in vivo
The transcription error rate estimated from mistakes in end product RNAs is 10(−3)–10(−5). We analyzed the fidelity of nascent RNAs from all actively transcribing elongation complexes (ECs) in Escherichia coli and Saccharomyces cerevisiae and found that 1–3% of all ECs in wild-type cells, and 5–7% o...
Gespeichert in:
| Veröffentlicht in: | Nucleic Acids Res |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5388426/ https://ncbi.nlm.nih.gov/pubmed/28180286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw969 |
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