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Transgenic rescue of Atg5-null mice from neonatal lethality with neuron-specific expression of ATG5: Systemic analysis of adult Atg5-deficient mice

Atg5-null mice are neonatal lethal. We have revealed in our recent paper that these mice die due to neuronal dysfunction resulting in suckling failure. Our new mouse model, atg5(–/–);Eno2/Nse-Atg5 mice, where Atg5 is deficient in the whole body except for neurons, enables us to analyze the consequen...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Yoshii, Saori R., Kuma, Akiko, Mizushima, Noboru
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388233/
https://ncbi.nlm.nih.gov/pubmed/28368776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1280221
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