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Neonatal Lethality of LGR5 Null Mice Is Associated with Ankyloglossia and Gastrointestinal Distension

The physiological role of an orphan G protein-coupled receptor, LGR5, was investigated by targeted deletion of this seven-transmembrane protein containing a large N-terminal extracellular domain with leucine-rich repeats. LGR5 null mice exhibited 100% neonatal lethality characterized by gastrointest...

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Publicado no:Mol Cell Biol
Principais autores: Morita, Hiroki, Mazerbourg, Sabine, Bouley, Donna M., Luo, Ching-Wei, Kawamura, Kazuhiro, Kuwabara, Yoshimitsu, Baribault, Helene, Tian, Hui, Hsueh, Aaron J. W.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2004
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC525477/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15509778/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.22.9736-9743.2004
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