Neonatal Lethality of LGR5 Null Mice Is Associated with Ankyloglossia and Gastrointestinal Distension

The physiological role of an orphan G protein-coupled receptor, LGR5, was investigated by targeted deletion of this seven-transmembrane protein containing a large N-terminal extracellular domain with leucine-rich repeats. LGR5 null mice exhibited 100% neonatal lethality characterized by gastrointest...

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Autores principales: Morita, Hiroki, Mazerbourg, Sabine, Bouley, Donna M., Luo, Ching-Wei, Kawamura, Kazuhiro, Kuwabara, Yoshimitsu, Baribault, Helene, Tian, Hui, Hsueh, Aaron J. W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC525477/
https://ncbi.nlm.nih.gov/pubmed/15509778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.22.9736-9743.2004
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