An Unliganded Thyroid Hormone β Receptor Activates the Cyclin D1/Cyclin-Dependent Kinase/Retinoblastoma/E2F Pathway and Induces Pituitary Tumorigenesis

Thyroid-stimulating hormone (TSH)-secreting tumors (TSH-omas) are pituitary tumors that constitutively secrete TSH. The molecular genetics underlying this abnormality are not known. We discovered that a knockin mouse harboring a mutated thyroid hormone receptor (TR) β (PV; TRβ(PV/PV) mouse) spontane...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Furumoto, Hiroko, Ying, Hao, Chandramouli, G. V. R., Zhao, Li, Walker, Robert L., Meltzer, Paul S., Willingham, Mark C., Cheng, Sheue-Yann
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2005
Assuntos:	Signal Transduction
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC538780/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15601836/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.25.1.124-135.2005
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