Ras-Raf-Arf Signaling Critically Depends on the Dmp1 Transcription Factor

Dmp1 prevents tumor formation by activating the Arf-p53 pathway. In cultured primary cells, the Dmp1 promoter was efficiently activated by oncogenic Ha-Ras(V12), but not by overexpressed c-Myc or E2F-1. Dmp1 promoter activation by Ras(V12) depended on Raf-MEK-ERK signaling. Induction of p19(Arf) and...

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Detalhes bibliográficos
Main Authors: Sreeramaneni, Ramesh, Chaudhry, Asif, McMahon, Martin, Sherr, Charles J., Inoue, Kazushi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC538777/
https://ncbi.nlm.nih.gov/pubmed/15601844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.1.220-232.2005
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