Membrane Fixation of Vascular Endothelial Growth Factor Receptor 1 Ligand-Binding Domain Is Important for Vasculogenesis and Angiogenesis in Mice

Vascular endothelial growth factor (VEGF) regulates vasculogenesis and angiogenesis by using two tyrosine kinase receptors, VEGFR1 and VEGFR2. VEGFR1 null mutant mice die on embryonic day 8.5 (E8.5) to E9.0 due to an overgrowth of endothelial cells and vascular disorganization, suggesting that VEGFR...

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Detalhes bibliográficos
Main Authors: Hiratsuka, Sachie, Nakao, Kazuki, Nakamura, Kenji, Katsuki, Motoya, Maru, Yoshiro, Shibuya, Masabumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC538773/
https://ncbi.nlm.nih.gov/pubmed/15601855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.1.346-354.2005
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