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Lysosomal Targeting of E-Cadherin: a Unique Mechanism for the Down-Regulation of Cell-Cell Adhesion during Epithelial to Mesenchymal Transitions

A hallmark characteristic of epithelial tumor progression as well as some processes of normal development is the loss of the epithelial phenotype and acquisition of a motile or mesenchymal phenotype. Such epithelial to mesenchymal transitions are accompanied by the loss of E-cadherin function by eit...

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Autori principali: Palacios, Felipe, Tushir, Jogender S., Fujita, Yasuyuki, D'Souza-Schorey, Crislyn
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC538771/
https://ncbi.nlm.nih.gov/pubmed/15601859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.1.389-402.2005
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