Increased tau Phosphorylation on Mitogen-Activated Protein Kinase Consensus Sites and Cognitive Decline in Transgenic Models for Alzheimer's Disease and FTDP-17: Evidence for Distinct Molecular Processes Underlying tau Abnormalities

Abnormal tau phosphorylation occurs in several neurodegenerative disorders, including Alzheimer's disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17). Here, we compare mechanisms of tau phosphorylation in mouse models of FTDP-17 and AD. Mice expressing a...

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Hlavní autoři: Lambourne, Sarah L., Sellers, Lynda A., Bush, Toby G., Choudhury, Shewly K., Emson, Piers C., Suh, Yoo-Hun, Wilkinson, Lawrence S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Mammalian Genetic Models with Minimal or Complex Phenotypes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC538769/
https://ncbi.nlm.nih.gov/pubmed/15601849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.1.278-293.2005
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