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Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling
De novo mutations in CHD8 are strongly associated with autism spectrum disorder (ASD), however the basic biology of CHD8 remains poor understood. Here we report that Chd8 knockdown during cortical development results in defective neural progenitor proliferation and differentiation that ultimately ma...
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| Udgivet i: | Nat Neurosci |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5386887/ https://ncbi.nlm.nih.gov/pubmed/27694995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4400 |
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