Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression

Both intracellular and extracellular heat shock protein-90 (Hsp90) family proteins (α and β) have been shown to support tumour progression. The tumour-supporting activity of the intracellular Hsp90 is attributed to their N-terminal ATPase-driven chaperone function. What molecular entity determines t...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Zou, M, Bhatia, A, Dong, H, Jayaprakash, P, Guo, J, Sahu, D, Hou, Y, Tsen, F, Tong, C, O'Brien, K, Situ, A J, Schmidt, T, Chen, M, Ying, Q, Ulmer, T S, Woodley, D T, Li, W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386837/
https://ncbi.nlm.nih.gov/pubmed/27721406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.375
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