Mitochondrial “power” drives tamoxifen resistance: NQO1 and GCLC are new therapeutic targets in breast cancer

Here, we identified two new molecular targets, which are functionally sufficient to metabolically confer the tamoxifen-resistance phenotype in human breast cancer cells. Briefly, ~20 proteins were first selected as potential candidates, based on unbiased proteomics analysis, using tamoxifen-resistan...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Fiorillo, Marco, Sotgia, Federica, Sisci, Diego, Cappello, Anna Rita, Lisanti, Michael P.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386764/
https://ncbi.nlm.nih.gov/pubmed/28411284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15852
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