BH3 mimetic-elicited Ca(2+) signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca(2+)-like peptides

BH3 mimetics are small-molecule inhibitors of B-cell lymphoma-2 (Bcl-2) and Bcl-xL, which disrupt the heterodimerisation of anti- and pro-apoptotic Bcl-2 family members sensitising cells to apoptotic death. These compounds have been developed as anti-cancer agents to counteract increased levels of B...

Full description

Saved in:
Bibliographic Details
Published in:Cell Death Dis
Main Authors: Ferdek, Pawel E, Jakubowska, Monika A, Nicolaou, Polina, Gerasimenko, Julia V, Gerasimenko, Oleg V, Petersen, Ole H
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
Subjects:
Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386550/
https://ncbi.nlm.nih.gov/pubmed/28252652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.41
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items