Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4

Coordination of energy metabolism is essential for homeostasis of stem cells, whereas an imbalance in energy homeostasis causes disease and accelerated aging. Here we show that deletion or enzymatic inactivation of lysine-specific demethylase 1 (Lsd1) triggers senescence in trophoblast stem cells (T...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Castex, Josefina, Willmann, Dominica, Kanouni, Toufike, Arrigoni, Laura, Li, Yan, Friedrich, Marcel, Schleicher, Michael, Wöhrle, Simon, Pearson, Mark, Kraut, Norbert, Méret, Michaël, Manke, Thomas, Metzger, Eric, Schüle, Roland, Günther, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386490/
https://ncbi.nlm.nih.gov/pubmed/28230862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.48
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