Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4

Coordination of energy metabolism is essential for homeostasis of stem cells, whereas an imbalance in energy homeostasis causes disease and accelerated aging. Here we show that deletion or enzymatic inactivation of lysine-specific demethylase 1 (Lsd1) triggers senescence in trophoblast stem cells (T...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cell Death Dis
मुख्य लेखकों: Castex, Josefina, Willmann, Dominica, Kanouni, Toufike, Arrigoni, Laura, Li, Yan, Friedrich, Marcel, Schleicher, Michael, Wöhrle, Simon, Pearson, Mark, Kraut, Norbert, Méret, Michaël, Manke, Thomas, Metzger, Eric, Schüle, Roland, Günther, Thomas
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group 2017
विषय:
Original Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386490/
https://ncbi.nlm.nih.gov/pubmed/28230862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.48
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