NGS-based transcriptome profiling reveals biomarkers for companion diagnostics of the TGF-β receptor blocker galunisertib in HCC

Transforming growth factor-beta (TGF-β) signaling has gained extensive interest in hepatocellular carcinoma (HCC). The small molecule kinase inhibitor galunisertib, targeting the TGF-β receptor I (TGF-βRI), blocks HCC progression in preclinical models and shows promising effects in ongoing clinical...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Cao, Yuan, Agarwal, Rahul, Dituri, Francesco, Lupo, Luigi, Trerotoli, Paolo, Mancarella, Serena, Winter, Peter, Giannelli, Gianluigi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386488/
https://ncbi.nlm.nih.gov/pubmed/28230858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.44
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