Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1

The antitumor effect of luteolin, a plant flavonoid, in gastric cancer (GC) cells has not been fully understood. Here we show that luteolin selectively kills STAT3 overactivated GC cells that are often drug resistant. The treatment of luteolin in these GC cells significantly inhibited STAT3 phosphor...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Song, Shiyu, Su, Zhonglan, Xu, Hui, Niu, Mengyuan, Chen, Xiufang, Min, Haiyan, Zhang, Bin, Sun, Guibo, Xie, Sijing, Wang, Hongwei, Gao, Qian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386483/
https://ncbi.nlm.nih.gov/pubmed/28182003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.38
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