Arsenic trioxide attenuates STAT-3 activity and epithelial-mesenchymal transition through induction of SHP-1 in gastric cancer cells

BACKGROUND: We investigated the effect of arsenic trioxide (ATO) for inhibition of signal transducer and activator of transcription 3 (STAT3) and epithelial-mesenchymal transition (EMT) in gastric cancer cells, and the role of SH2 domain-containing phosphatase-1 (SHP-1) during this process. METHODS:...

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Publicado no:BMC Cancer
Main Authors: Kim, Sung Ho, Yoo, Hyo Soon, Joo, Moon Kyung, Kim, Taehyun, Park, Jong-Jae, Lee, Beom Jae, Chun, Hoon Jai, Lee, Sang Woo, Bak, Young-Tae
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801683/
https://ncbi.nlm.nih.gov/pubmed/29409467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4071-9
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