Notch activation enhances mesenchymal stem cell sheet osteogenic potential by inhibition of cellular senescence

Our previous studies have confirmed the therapeutic effects of mesenchymal stem cell (MSC) monolayer sheet transplantation on allograft repair. A limiting factor in their application is the loss of MSC multi-potency as a result of high density sheet culture-induced senescence. In the study reported...

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Опубликовано в: :Cell Death Dis
Главные авторы: Tian, Ye, Xu, Ying, Xue, Taiyang, Chen, Longgang, Shi, Bin, Shu, Bing, Xie, Chao, Max Morandi, Massimo, Jaeblon, Todd, Marymont, John V, Dong, Yufeng
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386477/
https://ncbi.nlm.nih.gov/pubmed/28151468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.2
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