Notch activation enhances mesenchymal stem cell sheet osteogenic potential by inhibition of cellular senescence

Our previous studies have confirmed the therapeutic effects of mesenchymal stem cell (MSC) monolayer sheet transplantation on allograft repair. A limiting factor in their application is the loss of MSC multi-potency as a result of high density sheet culture-induced senescence. In the study reported...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Tian, Ye, Xu, Ying, Xue, Taiyang, Chen, Longgang, Shi, Bin, Shu, Bing, Xie, Chao, Max Morandi, Massimo, Jaeblon, Todd, Marymont, John V, Dong, Yufeng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386477/
https://ncbi.nlm.nih.gov/pubmed/28151468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.2
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