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Tenovin-6 impairs autophagy by inhibiting autophagic flux

Tenovin-6 has attracted significant interest because it activates p53 and inhibits sirtuins. It has anti-neoplastic effects on multiple hematopoietic malignancies and solid tumors in both in vitro and in vivo studies. Tenovin-6 was recently shown to impair the autophagy pathway in chronic lymphocyti...

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Bibliografiska uppgifter
I publikationen:Cell Death Dis
Huvudupphovsmän: Yuan, Hongfeng, Tan, Brandon, Gao, Shou-Jiang
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386474/
https://ncbi.nlm.nih.gov/pubmed/28182004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.25
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