RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function

Necroptosis is an inflammatory form of programmed cell death requiring receptor-interacting protein kinase 1, 3 (RIPK1, RIPK3) and mixed lineage kinase domain-like protein (MLKL). The kinase of RIPK3 phosphorylates MLKL causing MLKL to form a pore-like structure, allowing intracellular contents to r...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Hänggi, Kay, Vasilikos, Lazaros, Valls, Aida Freire, Yerbes, Rosario, Knop, Janin, Spilgies, Lisanne M, Rieck, Kristy, Misra, Tvisha, Bertin, John, Gough, Peter J, Schmidt, Thomas, de Almodòvar, Carmen Ruiz, Wong, W Wei-Lynn
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386469/
https://ncbi.nlm.nih.gov/pubmed/28151480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.20
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