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Adenosine A(2A) receptor deficiency attenuates the somnogenic effect of prostaglandin D(2) in mice
Prostaglandin D(2) (PGD(2)) is one of the most potent endogenous sleep promoting substances. PGD(2) activates the PGD(2) receptor (DPR) and increases the extracellular level of adenosine in wild-type (WT) mice but not DPR knockout (KO) mice, suggesting that PGD(2)-induced sleep is DPR-dependent, and...
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| Publicado no: | Acta Pharmacol Sin |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5386310/ https://ncbi.nlm.nih.gov/pubmed/28112177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.140 |
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