Adenosine A(2A) receptor deficiency attenuates the somnogenic effect of prostaglandin D(2) in mice

Prostaglandin D(2) (PGD(2)) is one of the most potent endogenous sleep promoting substances. PGD(2) activates the PGD(2) receptor (DPR) and increases the extracellular level of adenosine in wild-type (WT) mice but not DPR knockout (KO) mice, suggesting that PGD(2)-induced sleep is DPR-dependent, and...

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Enregistré dans:
Détails bibliographiques
Publié dans:Acta Pharmacol Sin
Auteurs principaux: Zhang, Bin-jia, Huang, Zhi-li, Chen, Jiang-fan, Urade, Yoshihiro, Qu, Wei-min
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386310/
https://ncbi.nlm.nih.gov/pubmed/28112177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.140
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