Reduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome

The 22q11.2 deletion syndrome (22q11.2DS; velo-cardio-facial syndrome; DiGeorge syndrome) is a congenital anomaly disorder in which haploinsufficiency of TBX1, encoding a T-box transcription factor, is the major candidate for cardiac outflow tract (OFT) malformations. Inactivation of Tbx1 in the ant...

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Dades bibliogràfiques
Publicat a:PLoS Genet
Autors principals: Racedo, Silvia E., Hasten, Erica, Lin, Mingyan, Devakanmalai, Gnanapackiam Sheela, Guo, Tingwei, Ozbudak, Ertugrul M., Cai, Chen-Leng, Zheng, Deyou, Morrow, Bernice E.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386301/
https://ncbi.nlm.nih.gov/pubmed/28346476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006687
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