Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear

Behavioural anomalies suggesting an inner ear disorder were observed in a colony of transgenic mice. Affected animals were profoundly deaf. Severe hair bundle defects were identified in all outer and inner hair cells (OHC, IHC) in the cochlea and in hair cells of vestibular macular organs, but hair...

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Publicado en:PLoS Genet
Autores principales: Forge, Andrew, Taylor, Ruth R., Dawson, Sally J., Lovett, Michael, Jagger, Daniel J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386298/
https://ncbi.nlm.nih.gov/pubmed/28346477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006692
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