Association between LDL-cholesterol lowering genetic variants and risk of type 2 diabetes

IMPORTANCE: Low-density lipoprotein (LDL) cholesterol-lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and statins, have previously been used as proxies to study the efficacy of these lipid-lowering drugs. Alleles near HMGCR are associated with a hi...

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Publicado no:JAMA
Main Authors: Lotta, Luca A., Sharp, Stephen. J, Burgess, Stephen, Perry, John R. B., Stewart, Isobel. D, Willems, Sara M., Luan, Jian’an, Ardanaz, Eva, Arriola, Larraitz, Balkau, Beverley, Boeing, Heiner, Deloukas, Panos, Forouhi, Nita G, Franks, Paul W, Grioni, Sara, Kaaks, Rudolf, Key, Timothy J, Navarro, Carmen, Nilsson, Peter M, Overvad, Kim, Palli, Domenico, Panico, Salvatore, Quirós, Jose-Ramón, Riboli, Elio, Rolandsson, Olov, Sacerdote, Carlotta, Salamanca, Elena C, Slimani, Nadia, Spijkerman, Annemieke MW, Tjonneland, Anne, Tumino, Rosario, van der A, Daphne L, van der Schouw, Yvonne T, McCarthy, Mark I., Barroso, Inês, O’Rahilly, Stephen, Savage, David. B, Sattar, Naveed, Langenberg, Claudia, Scott, Robert. A, Wareham, Nicholas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386134/
https://ncbi.nlm.nih.gov/pubmed/27701660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2016.14568
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