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Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner

Accumulation of mechanical stresses during cancer progression can induce blood and lymphatic vessel compression, creating hypo-perfusion, hypoxia and interstitial hypertension which decrease the efficacy of chemo- and nanotherapies. Stress alleviation treatment has been recently proposed to reduce m...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Papageorgis, Panagiotis, Polydorou, Christiana, Mpekris, Fotios, Voutouri, Chrysovalantis, Agathokleous, Eliana, Kapnissi-Christodoulou, Constantina P., Stylianopoulos, Triantafyllos
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385877/
https://ncbi.nlm.nih.gov/pubmed/28393881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46140
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