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Targeted activation of diverse CRISPR-Cas systems for mammalian genome editing via proximal CRISPR targeting
Bacterial CRISPR–Cas systems comprise diverse effector endonucleases with different targeting ranges, specificities and enzymatic properties, but many of them are inactive in mammalian cells and are thus precluded from genome-editing applications. Here we show that the type II-B FnCas9 from Francise...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5385574/ https://ncbi.nlm.nih.gov/pubmed/28387220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14958 |
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