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Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection
Cell surface aminopeptidase N (APN) is a membrane-bound ectoenzyme that hydrolyzes proteins and peptides and regulates numerous cell functions. APN participates in tumor cell expansion and motility, and is a target for cancer therapies. Small drugs that bind to the APN active site inhibit catalysis...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5385526/ https://ncbi.nlm.nih.gov/pubmed/28393915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46045 |
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