The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24.

We cloned the t(10;14) recurrent translocation from CD3-negative T-cell acute lymphoblastic leukemia cells. The breakpoint at 14q11 involved an intermediate rearrangement of the delta T-cell receptor locus, suggesting that the translocation arose at the time of antigen receptor assemblage. Transloca...

Full description

Saved in:
Bibliographic Details
Main Authors: Zutter, M, Hockett, R D, Roberts, C W, McGuire, E A, Bloomstone, J, Morton, C C, Deaven, L L, Crist, W M, Carroll, A J, Korsmeyer, S J
Format: Artigo
Language:Inglês
Published: 1990
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC53854/
https://ncbi.nlm.nih.gov/pubmed/2326274
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items