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The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24.

We cloned the t(10;14) recurrent translocation from CD3-negative T-cell acute lymphoblastic leukemia cells. The breakpoint at 14q11 involved an intermediate rearrangement of the delta T-cell receptor locus, suggesting that the translocation arose at the time of antigen receptor assemblage. Transloca...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Zutter, M, Hockett, R D, Roberts, C W, McGuire, E A, Bloomstone, J, Morton, C C, Deaven, L L, Crist, W M, Carroll, A J, Korsmeyer, S J
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1990
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53854/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2326274/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.8.3161
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