Anti-Human Immunodeficiency Virus Type 1 (HIV-1) Antibodies 2F5 and 4E10 Require Surprisingly Few Crucial Residues in the Membrane-Proximal External Region of Glycoprotein gp41 To Neutralize HIV-1

The conserved membrane-proximal external region (MPER) of human immunodeficiency virus type 1 (HIV-1) gp41 is a target of two broadly neutralizing human monoclonal antibodies, 2F5 and 4E10, and is an important lead for vaccine design. However, immunogens that bear MPER epitopes so far have not elici...

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Bibliografiska uppgifter
Huvudupphovsmän: Zwick, Michael B., Jensen, Richard, Church, Sarah, Wang, Meng, Stiegler, Gabriela, Kunert, Renate, Katinger, Hermann, Burton, Dennis R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2005
Ämnen:
Pathogenesis and Immunity
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC538539/
https://ncbi.nlm.nih.gov/pubmed/15613352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.2.1252-1261.2005
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