A diagnostic microdosing approach to study gemcitabine resistance

Gemcitabine metabolites cause termination of DNA replication and induction of apoptosis. We determined whether subtherapeutic “microdoses” of gemcitabine are incorporated into DNA at levels that correlate to drug cytotoxicity. A pair of nearly isogenic bladder cancer cell lines differing in resistan...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Chem Res Toxicol
Autors principals: Scharadin, Tiffany M., Zhang, Hongyong, Zimmermann, Maike, Wang, Sisi, Malfatti, Michael A., Cimino, George D., Turteltaub, Kenneth, de Vere White, Ralph, Pan, Chong-xian, Henderson, Paul T.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385140/
https://ncbi.nlm.nih.gov/pubmed/27657672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00247
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars