SynthEx: a synthetic-normal-based DNA sequencing tool for copy number alteration detection and tumor heterogeneity profiling

Changes in the quantity of genetic material, known as somatic copy number alterations (CNAs), can drive tumorigenesis. Many methods exist for assessing CNAs using microarrays, but considerable technical issues limit current CNA calling based upon DNA sequencing. We present SynthEx, a novel tool for...

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Detaylı Bibliyografya
Yayımlandı:Genome Biol
Asıl Yazarlar: Silva, Grace O., Siegel, Marni B., Mose, Lisle E., Parker, Joel S., Sun, Wei, Perou, Charles M., Chen, Mengjie
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2017
Konular:
Method
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385048/
https://ncbi.nlm.nih.gov/pubmed/28390427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1193-3
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