Mapping mitochondrial heteroplasmy in a Leydig tumor by laser capture micro-dissection and cycling temperature capillary electrophoresis

BACKGROUND: The growth of tumor cells is accompanied by mutations in nuclear and mitochondrial genomes creating marked genetic heterogeneity. Tumors also contain non-tumor cells of various origins. An observed somatic mitochondrial mutation would have occurred in a founding cell and spread through c...

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Detaylı Bibliyografya
Yayımlandı:BMC Clin Pathol
Asıl Yazarlar: Refinetti, Paulo, Arstad, Christian, Thilly, William G., Morgenthaler, Stephan, Ekstrøm, Per Olaf
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2017
Konular:
Technical Advance
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385042/
https://ncbi.nlm.nih.gov/pubmed/28405177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12907-017-0042-3
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