Normal diploid human and rodent cells lack a detectable frequency of gene amplification.
Gene amplification is frequently observed in tumors and transformed cell lines. This phenomenon is known to contribute to the generation of drug-resistant tumor cells and quantitation of the event is believed to have prognostic value in several types of neoplasias. To date, most studies of gene ampl...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1990
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53848/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2326271/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.8.3132 |
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