PD-L1 (CD274) copy number gain, expression, and immune cell infiltration as candidate predictors for response to immune checkpoint inhibitors in soft-tissue sarcoma

Soft-tissue sarcomas (STS) are rare malignancies that account for 1% of adult cancers and comprise more than 50 entities. Current therapeutic options for advanced-stage STS are limited. Immune checkpoint inhibitors targeting the PD-1/PD-L1 signaling axis are being explored as new treatment modality...

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Dettagli Bibliografici
Pubblicato in:Oncoimmunology
Autori principali: Budczies, Jan, Mechtersheimer, Gunhild, Denkert, Carsten, Klauschen, Frederick, Mughal, Sadaf S., Chudasama, Priya, Bockmayr, Michael, Jöhrens, Korinna, Endris, Volker, Lier, Amelie, Lasitschka, Felix, Penzel, Roland, Dietel, Manfred, Brors, Benedikt, Gröschel, Stefan, Glimm, Hanno, Schirmacher, Peter, Renner, Marcus, Fröhling, Stefan, Stenzinger, Albrecht
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2017
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384369/
https://ncbi.nlm.nih.gov/pubmed/28405504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1279777
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