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High expression of PD-1 ligands is associated with kataegis mutational signature and APOBEC3 alterations

Immunotherapy with checkpoint inhibitors, such as antibodies blocking the programmed cell-death receptor-1 (PD-1), has resulted in remarkable responses in patients having traditionally refractory cancers. Although response to PD-1 inhibitors correlates with PD-1 ligand (PD-L1 or PD-L2) expression, P...

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Vydáno v:Oncoimmunology
Hlavní autoři: Boichard, Amélie, Tsigelny, Igor F., Kurzrock, Razelle
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384346/
https://ncbi.nlm.nih.gov/pubmed/28405512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1284719
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