PRC2 is required to maintain expression of the maternal Gtl2-Rian-Mirg locus by preventing de novo DNA methylation in mouse embryonic stem cells

Polycomb Repressive Complex 2 (PRC2) function and DNA methylation (DNAme) are typically correlated with the gene repression. Here, we show that PRC2 is required to maintain expression of maternal microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) from the Gtl2-Rian-Mirg locus, which is essential...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Das, Partha Pratim, Hendrix, David A., Apostolou, Effie, Buchner, Alice H., Canver, Matthew C., Beyaz, Semir, Ljuboja, Damir, Kuintzle, Rachael, Kim, Woojin, Karnik, Rahul, Shao, Zhen, Xie, Huafeng, Xu, Jian, De Los Angeles, Alejandro, Zhang, Yingying, Choe, Junho, Jun, Don Leong Jia, Shen, Xiaohua, Gregory, Richard I., Daley, George Q., Meissner, Alexander, Kellis, Manolis, Hochedlinger, Konrad, Kim, Jonghwan, Orkin, Stuart H.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384103/
https://ncbi.nlm.nih.gov/pubmed/26299972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.053
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