Granzyme B enters the mitochondria in a Sam50-, Tim22- and mtHsp70-dependent manner to induce apoptosis

We have found that granzyme B (GB)-induced apoptosis also requires reactive oxygen species resulting from the alteration of mitochondrial complex I. How GB, which does not possess a mitochondrial targeting sequence, enter this organelle is unknown. We show that GB enters the mitochondria independent...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Chiusolo, Valentina, Jacquemin, Guillaume, Yonca Bassoy, Esen, Vinet, Laurent, Liguori, Lavinia, Walch, Michael, Kozjak-Pavlovic, Vera, Martinvalet, Denis
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384031/
https://ncbi.nlm.nih.gov/pubmed/28338658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.3
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