STAT1 mediates transmembrane TNF-alpha-induced formation of death-inducing signaling complex and apoptotic signaling via TNFR1

Tumor necrosis factor-alpha (TNF-α) exists in two forms: secretory TNF-α (sTNF-α) and transmembrane TNF-α (tmTNF-α). Although both forms of TNF-α induce tumor cell apoptosis, tmTNF-α is able to kill tumor cells that are resistant to sTNF-α-mediated cytotoxicity, indicating their differences in signa...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Jiang, Yaping, Yu, Min, Hu, Xuena, Han, Lu, Yang, Kun, Ba, Hongping, Zhang, Zunyue, Yin, Bingjiao, Yang, Xiang-Ping, Li, Zhuoya, Wang, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384023/
https://ncbi.nlm.nih.gov/pubmed/28186502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.162
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