A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation

Most myeloproliferative neoplasm (MPN) patients lacking JAK2 mutations harbour somatic CALR mutations that are thought to activate cytokine signalling although the mechanism is unclear. To identify kinases important for survival of CALR-mutant cells, we developed a novel strategy (KISMET) that utili...

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Détails bibliographiques
Publié dans:Leukemia
Auteurs principaux: Kollmann, K, Warsch, W, Gonzalez-Arias, C, Nice, F L, Avezov, E, Milburn, J, Li, J, Dimitropoulou, D, Biddie, S, Wang, M, Poynton, E, Colzani, M, Tijssen, M R, Anand, S, McDermott, U, Huntly, B, Green, T
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5383931/
https://ncbi.nlm.nih.gov/pubmed/27740635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.280
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