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A role for the spindle assembly checkpoint in the DNA damage response

Spontaneous DNA damage poses a continuous threat to genomic integrity. If unchecked, genotoxic insults result in genomic instability, a hallmark of cancer cells. In eukaryotic cells a DNA Damage Response (DDR) detects and responds to genotoxic stress, acting as an anti-cancer barrier in humans. Amon...

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Détails bibliographiques
Publié dans:Curr Genet
Auteurs principaux: Palou, Roger, Palou, Gloria, Quintana, David G.
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5383677/
https://ncbi.nlm.nih.gov/pubmed/27488803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00294-016-0634-y
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