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A role for the spindle assembly checkpoint in the DNA damage response
Spontaneous DNA damage poses a continuous threat to genomic integrity. If unchecked, genotoxic insults result in genomic instability, a hallmark of cancer cells. In eukaryotic cells a DNA Damage Response (DDR) detects and responds to genotoxic stress, acting as an anti-cancer barrier in humans. Amon...
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| Published in: | Curr Genet |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Springer Berlin Heidelberg
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5383677/ https://ncbi.nlm.nih.gov/pubmed/27488803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00294-016-0634-y |
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