Elevated expression of DNMT1 is associated with increased expansion and proliferation of hematopoietic stem cells co-cultured with human MSCs

BACKGROUND: Mesenchymal stem cells (MSCs) play an important role in hematopoietic stem cell (HSC) maintenance, proliferation, and apoptosis. DNA methyltransferase 1 (DNMT1) is considered an essential factor in the maintenance of HSCs in mammalian cells. Therefore, this study was conducted to evaluat...

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Vydáno v:Blood Res
Hlavní autoři: Ahmadnejad, Moharram, Amirizadeh, Naser, Mehrasa, Roya, Karkhah, Ahmad, Nikougoftar, Mahin, Oodi, Arezoo
Médium: Artigo
Jazyk:Inglês
Vydáno: Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2017
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5383583/
https://ncbi.nlm.nih.gov/pubmed/28401098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5045/br.2017.52.1.25
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