Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction

Cancer cells depend on glutamine to sustain their increased proliferation and manage oxidative stress, yet glutamine is often depleted at tumor sites due to excessive cellular consumption and poor vascularization. We have previously reported that p53 protein, while a well-known tumor suppressor, can...

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Veröffentlicht in:Oncogene
Hauptverfasser: Tran, Thai Q., Lowman, Xazmin H., Reid, Michael A., Mendez-Dorantes, Carlos, Pan, Min, Yang, Ying, Kong, Mei
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5383530/
https://ncbi.nlm.nih.gov/pubmed/27721412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.360
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